Skeletal stressing method and apparatus Patent

Method and apparatus for applying compressional forces to skeletal structure of subject to simulate force during ambulatory condition

Weight simulator

Device applies compressive force to bone to minimize loss of bone calcium during weightlessness or bedrest. Force is applied through weights, or hydraulic, pneumatic or electrically actuated devices. Device is lightweight and easy to maintain and operate

Programmable physiological infusion

A programmable physiological infusion device and method are provided wherein a program source, such as a paper tape, is used to actuate an infusion pump in accordance with a desired program. The system is particularly applicable for dispensing calcium in a variety of waveforms

Programmed physiological infusion system

Infusion system delivers incremental volumes from a reservoir with a piston pump at a rate that varies in time and follows the envelope of a preprogrammed curve

Kinematic study of flight telerobotic servicer configuration issues

Several factors, such as body size and shape, and the number of arms and their placement, will influence how well the Flight Telerobotic Servicer (FTS) is suited to its potential duties for the Space Station Program. In order to examine the implications of these configuration options, eight specific 2, 3, and 4 armed FTS configuration were simulated and used to perform a Space Station Orbital Replacement Unit (ORU) exchange. The strengths and weaknesses of each configuration were evaluated. Although most of the configurations examined were able to perform the exchange, several of the 3 and 4 arm configurations had operational advantages. The results obtained form these simulations are specific to the assumptions associated with the ORU exchange scenario examined. However, they do illustrate the general interrelationships and sensitivities which need to be understood

Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis.

11 p.-4 fig.-1 tab.Background: Increased circulating levels of endoglin+ endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth factor β (TGF-β) important in the regulation of vascular structure.Results: We quantified the number of microparticles in plasma of six patients with chronic thromboembolic pulmonary hypertension (CTEPH) and age- and sex-matched pulmonary embolic (PE) and healthy controls and investigated the role of microparticle endoglin in the regulation of pulmonary endothelial function in vitro. Results show significantly increased levels of endoglin+ EMPs in CTEPH plasma, compared to healthy and disease controls. Co-culture of human pulmonary endothelial cells with CTEPH microparticles increased intracellular levels of endoglin and enhanced TGF-β-induced angiogenesis and Smad1,5,8 phosphorylation in cells, without affecting BMPRII expression. In an in vitro model, we generated endothelium-derived MPs with enforced membrane localization of endoglin. Co-culture of these MPs with endothelial cells increased cellular endoglin content, improved cell survival and stimulated angiogenesis in a manner similar to the effects induced by overexpressed protein.Conclusions: Increased generation of endoglin+ EMPs in CTEPH is likely to represent a protective mechanism supporting endothelial cell survival and angiogenesis, set to counteract the effects of vascular occlusion and endothelial damage.This research was supported by a project grant (PG 11/13/28765) from the British Heart Foundation and by grants from Ministerio de Economia y Competitividad of Spain (SAF2013-43421-R to CB)Peer reviewe